Key result
Removal of the renal artery clip in hypertensive rats rapidly reduced blood pressure independently of the renin-angiotensin system, suggesting involvement of a renal vasodepressor system.
Why the study?
Does surgical removal of the renal artery clip reduce blood pressure and renin concentrations in Goldblatt two-kidney one-clip hypertensive rats?
Population
Goldblatt two-kidney one-clip hypertensive rats
Comparison
Surgical correction by removing the renal artery… vs Baseline (before surgical correction)
Design
Preclinical
Follow-up
24 hours
Authors
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Hypothesis-generating for a renal vasodepressor system in experimental hypertension; leaves open any role in human renovascular disease.
Does surgical removal of the renal artery clip reduce blood pressure and renin concentrations in Goldblatt two-kidney one-clip hypertensive rats?
The reduction in blood pressure following renal artery unclipping in hypertensive rats is not solely dependent on the renin-angiotensin system, suggesting a role for a renal vasodepressor system.
Brice et al. (1983) studied Goldblatt two-kidney one-clip hypertension. Surgical correction by removing the renal artery clip vs. Before surgical correction (baseline) was evaluated on Blood pressure, plasma and aortic renin concentrations. Removal of the renal artery clip in hypertensive rats rapidly reduced blood pressure independently of the renin-angiotensin system, suggesting involvement of a renal vasodepressor system.
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