Why the study?
Does modulation of the ACE2-Ang-(1-7)-Mas axis affect the course of hypertension and renal function in 2K1C Goldblatt hypertensive rats?
Does modulation of the ACE2-Ang-(1-7)-Mas axis affect the course of hypertension and renal function in 2K1C Goldblatt hypertensive rats?
Impairment of the ACE2-Ang-(1-7)-Mas axis worsens hypertension and renal hemodynamics in a rat model of renovascular hypertension, supporting its role as an endogenous vasodilator system.
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Supports protective role of ACE2-Ang-(1-7)-Mas axis in experimental renovascular hypertension; hypothesis-generating with no clinical implications yet.
Bürgelová et al. (2009) studied this question.
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