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January 28, 2016AJP Renal Physiology

In 2K1C rats, attenuated ACE2 was observed at 2 weeks (initiating hypertension), while upregulated ACE and unsuppressed AT1R were present at 5 weeks (maintaining hypertension).

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Population

Sprague-Dawley rats

Comparison

Insertion of a 2.5-mm clip into the left renal… vs Sham operation

Design

Preclinical

Follow-up

5 weeks

Authors

YKYang‐Gyun KimSLSang Ho LeeSKSeyun Kim

Discussion

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Overview

Hypothesis-generating for phased RAS changes in renovascular hypertension; leaves open human translation and therapeutic timing.

Structured PICO

P
Population
Sprague-Dawley rats
I
Intervention
Insertion of a 2.5-mm clip into the left renal artery (two-kidney, one-clip [2K1C] model)
C
Comparator
Sham operation
O
Outcome
Expression of intrarenal renin-angiotensin system components (renin, ACE, ACE2, AT1R, MasR) and blood pressuresurrogate

In a 2K1C rat model, attenuated ACE2 contributes to initiating hypertension, while upregulated ACE and unsuppressed AT1R maintain it.

Cite This Study

Kim et al. (2016) studied this question.

synapsesocial.com/papers/6a856a7302a1bc3ea31e59dchttps://doi.org/10.1152/ajprenal.00001.2015
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