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July 1, 1986Hypertension

Vascular renin-angiotensin system in two-kidney, one clip hypertensive rats.

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Key result

In chronically renal hypertensive rats, enalapril or 1-sarcosine, 8-isoleucine angiotensin II lowered blood pressure, suggesting the vascular renin-angiotensin system maintains hypertension.

Population

Two-kidney, one clip hypertensive rats

Comparison

1-sarcosine, 8-isoleucine angiotensin II or… vs Age-matched normotensive rats

Design

Preclinical

Follow-up

16 weeks

Authors

TOTomonori OkamuraPreventive CardiologyMMMizuo MiyazakiOsaka Medical and Pharmaceutical UniversityTITadashi InagamiHeart Failure / Cardiomyopathy

Discussion

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Implication

Supports vascular renin-angiotensin system in rat renal hypertension models; leaves open human translation and therapeutic relevance.

Key Points

  • This study examines the role of the renin-angiotensin system in sustaining high blood pressure in a specific hypertension model.
  • Analyzed plasma renin activity over time following renal artery clipping in rats.
  • Measured angiotensin converting enzyme activity in plasma and vascular tissues.
  • Tested effects of angiotensin II and enalapril on blood pressure and enzyme activity.”],
  • Significant increase in plasma renin activity with blood pressure elevation followed by a gradual decrease.
  • Vascular angiotensin converting enzyme activity increased significantly at chronic stages of hypertension (P<0.01).
  • Enalapril treatment lowered blood pressure and decreased vascular angiotensin converting enzyme activity.

Structured PICO

P
Population
Two-kidney, one clip hypertensive rats evaluated for the role of the vascular renin-angiotensin system in maintaining hypertension.
I
Intervention
1-sarcosine, 8-isoleucine angiotensin II or enalapril
C
Comparator
Age-matched normotensive rats (for isolated artery experiments)
O
Outcome
Blood pressure, plasma and tissue renin activity, and angiotensin converting enzyme (ACE) activitysurrogate

The vascular renin-angiotensin system plays a key role in maintaining hypertension in the two-kidney, one clip rat model via elevated vascular ACE activity.

Cite This Study

Okamura et al. (1986) studied Two-kidney, one clip hypertension. 1-sarcosine, 8-isoleucine angiotensin II or enalapril vs. Age-matched normotensive rats was evaluated on Blood pressure and renin/angiotensin converting enzyme activity. In chronically renal hypertensive rats, enalapril or 1-sarcosine, 8-isoleucine angiotensin II lowered blood pressure, suggesting the vascular renin-angiotensin system maintains hypertension.

synapsesocial.com/papers/6a202291c1b320180d0dfd94https://doi.org/10.1161/01.hyp.8.7.560
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Blood Pressure Response of Nephrectomized Hypertensive Rats to Converting Enzyme Inhibition: Evidence for Persistent Vascular Renin Activity1977 · 61 citations
  2. 2Arterial Wall Renin and Renal Venous Renin in the Hypertensive Rat1979 · 61 citations
  3. 3Vascular Neuroeffector Function in Two-Kidney, One Clip Hypertensive Dogs1985 · 12 citations
  4. 4Comparison of Angiotensin II Antagonist and Antiserum Infusion with Nephrectomy in the Rat with Two-Kidney Goldblatt Hypertension1974 · 56 citations
  5. 5Renin substrate in rat mesenteric artery1981 · 35 citations