Why the study?
Is local vascular formation of angiotensin II increased in one-kidney, one clip hypertensive rats?
Population
One-kidney, one clip hypertensive rats and age-matched normotensive rats
Comparison
Administration of angiotensin II, angiotensin I… vs Age-matched normotensive rats and untreated…
Design
Preclinical
Follow-up
7 and 30 days after clipping
Authors
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Augmented local vascular angiotensin II formation in experimental hypertension; leaves open relevance to human disease and therapeutic targeting.
Is local vascular formation of angiotensin II increased in one-kidney, one clip hypertensive rats?
Local formation of angiotensin II is increased in the arteries of one-kidney, one clip hypertensive rats, suggesting an important role for nonrenin proteases in vascular angiotensin II formation.
Leite et al. (1992) studied this question.
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