What question did this study set out to answer?

To evaluate how competitive blockade of angiotensin II affects blood pressure in rats with two-kidney, one-clip renal hypertension.

November 1, 1975Circulation ResearchOpen Access

Effect of the angiotensin II blocker 1-Sar-8-Ala-angiotensin II on renal artery clip hypertension in the rat.

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Why the study?

Does 1-Sar-8-Ala-angiotensin II infusion reduce blood pressure in rats with renal artery clip hypertension?

Population

24 conscious male Wistar rats with hypertension induced by left renal artery clipping

Design

Preclinical

Authors

GMGraham MacdonaldNHS Grampian GBG. W. BoydUniversity of Tasmania WPW. S. PeartUniversity of Southern California

Discussion

Member takes

Implication

Supports angiotensin dependence in this rat model; leaves open translation to human renovascular hypertension.

Key Points

To evaluate how competitive blockade of angiotensin II affects blood pressure in rats with two-kidney, one-clip renal hypertension.
Administered intravenous infusions of the competitive antagonist 1-Sar-8-Ala-angiotensin II to N=24 conscious male Wistar rats with left renal artery clip-induced hypertension.
Measured blood pressure alterations alongside baseline plasma renin activity, blood urea levels, duration since clipping, and response to subsequent nephrectomy of the clipped kidney.
Blood pressure response during antagonist infusion correlated strongly with baseline plasma renin activity (r = -0.78, P < 0.01), but not with blood urea (r = 0.27, 0.1 > P > 0.05) or time since clipping (r = 0.02, P > 0.05).
Rats exhibiting blood pressure decreases greater than 20 mm Hg remained above normotensive ranges, whereas surgical excision of the clipped kidney normalized blood pressure within 24 hours.

Structured PICO

Does 1-Sar-8-Ala-angiotensin II infusion reduce blood pressure in rats with renal artery clip hypertension?

Population

24 conscious male Wistar rats with hypertension induced by left renal artery clipping (two-kidney hypertension)

Intervention

Intravenous infusion of 1-Sar-8-Ala-angiotensin II (a competitive angiotensin II antagonist)

Outcome

Change in blood pressuresurrogate

The blood pressure response to angiotensin II blockade in renal clip hypertension correlates with baseline plasma renin activity, suggesting dependence on circulating angiotensin rather than increased sensitivity.

Cite This Study

Macdonald et al. (1975) studied this question.

synapsesocial.com/papers/6a8be68e039371f2a38971e2 https://doi.org/10.1161/01.res.37.5.640

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Effect of the angiotensin II blocker 1-Sar-8-Ala-angiotensin II on renal artery clip hypertension in the rat.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effect of the angiotensin II blocker 1-Sar-8-Ala-angiotensin II on renal artery clip hypertension in the rat.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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