Key result
In rats with two-kidney one-clip hypertension, intrarenal Angiotensin II was elevated in the clipped kidney but failed to suppress in the contralateral kidney compared to controls.
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Does not inform clinical hypertension management; leaves open intrarenal Ang II mechanisms in renovascular models.
F. A. O. Mendelsohn (1980) studied Two-kidney one-clip hypertension. Application of a 0.20 mm clip to the left renal artery vs. Sham-operated rats / controls was evaluated on Intrarenal Angiotensin II (AII) and kidney renin levels. In rats with two-kidney one-clip hypertension, intrarenal Angiotensin II was elevated in the clipped kidney but failed to suppress in the contralateral kidney compared to controls.
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