Why the study?
Does renal artery stenosis enhance the slow pressor effect of Angiotensin II in a rat model of hypertension?
Population
Rats submitted to either renal artery clipping or sham operation
Comparison
Enalapril in drinking water for 10 to 14 days… vs Sham-operated rats receiving the same enalapril…
Design
Preclinical
Follow-up
14 days of Angiotensin II infusion
Authors
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Renal artery stenosis may augment Ang II responsiveness in this rat model; leaves open translation to human renovascular hypertension.
Does renal artery stenosis enhance the slow pressor effect of Angiotensin II in a rat model of hypertension?
Renal artery stenosis enhances the responsiveness to the slow pressor effect of Angiotensin II in a rat model of Goldblatt hypertension.
Melaragno et al. (1995) studied this question.
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