Key result
Acute administration of Tempol reduced mean arterial pressure by 35% and increased cortical blood flow by 35% and medullary oxygen tension by 94% in the clipped kidney of chronic 2K,1C rats.
Why the study?
Does acute administration of Tempol, candesartan, or enalaprilat improve mean arterial pressure, renal blood flow, and oxygenation in chronic 2K,1C rats?
Population
Chronic 2-kidney, 1-clip Goldblatt hypertensive rats and sham controls
Comparison
Acute administration of Tempol followed by… vs Sham controls
Design
Preclinical
Follow-up
Acute administration (12 months post-clipping)
Authors
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These preclinical findings are hypothesis-generating; clinical translation studies are required before considering human use.
Does acute administration of Tempol, candesartan, or enalaprilat improve mean arterial pressure, renal blood flow, and oxygenation in chronic 2K,1C rats?
In chronic 2K,1C hypertensive rats, acute administration of the ROS inhibitor Tempol is more effective than candesartan in reducing blood pressure and improving renal perfusion and oxygenation.
Palm et al. (2010) studied Chronic 2-kidney, 1-clip (2K,1C) hypertension. Tempol, candesartan, and enalaprilat vs. Sham controls was evaluated on Mean arterial pressure, renal cortical blood flow, and renal cortical and medullary oxygen tension. Acute administration of Tempol reduced mean arterial pressure by 35% and increased cortical blood flow by 35% and medullary oxygen tension by 94% in the clipped kidney of chronic 2K,1C rats.
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