Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
February 1, 1992HypertensionOpen Access

Possible role of the vascular renin-angiotensin system in hypertension and vascular hypertrophy.

View Full Paper
Ask AI
Bookmark
Share

Population

Two-kidney, one clip (2K1C) hypertension rats and control rats

Comparison

Two-kidney, one clip (2K1C) hypertension model vs Control rats

Design

Preclinical

Follow-up

16 weeks

Authors

RMRyuichi MorishitaVascular / Pulmonary VascularJHJitsuo HigakiGeneral / Preventive / LipidsMMMizuo MiyazakiOsaka Medical and Pharmaceutical University

Discussion

Loading...

Member takes

Implication

No direct clinical implications from this rat model; leaves open vascular Ang II role in human renovascular disease progression.

Structured PICO

P
Population
Two-kidney, one clip (2K1C) hypertension rats and control rats
I
Intervention
Two-kidney, one clip (2K1C) hypertension model
C
Comparator
Control rats
O
Outcome
Aortic angiotensinogen mRNA, aortic and plasma angiotensin II (Ang II) concentration, and morphological arteriosclerotic changes (wall-to-lumen ratio)surrogate

Elevated vascular Ang II levels and concomitant morphological arteriosclerotic changes occur during both early and chronic phases of 2K1C hypertension in rats.

Cite This Study

Morishita et al. (1992) studied this question.

synapsesocial.com/papers/6a6f9be635aa2c282ce0f390https://doi.org/10.1161/01.hyp.19.2_suppl.ii62
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Vascular renin-angiotensin system in two-kidney, one clip hypertensive rats.1986 · 191 citations
  2. 2Effects of chronic inhibition of converting enzyme on mechanical and structural properties of arteries in rat renovascular hypertension.1988 · 219 citations
  3. 3Converting enzyme inhibitors regressed cardiac hypertrophy and reduced tissue angiotensin II in spontaneously hypertensive rats1991 · 94 citations
  4. 4Angiotensin II-induced proliferation of aortic myocytes in spontaneously hypertensive rats1990 · 176 citations
  5. 5Angiotensin formation in the isolated rat hindlimb1989 · 68 citations