March 1, 1996The Journal of Urology

Role of Dopamine in the Striatum, Renin-Angiotensin System and Renal Sympathetic Nerve on the Development of Two-Kidney, One-Clip Goldblatt Hypertension

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Population

Rats

Comparison

Two-kidney, one-clip Goldblatt hypertension… vs Sham-operated rats

Design

Preclinical

Follow-up

Up to 3 weeks

Authors

TST. SawamuraYamagata University TNTeruhiro NakadaYamagata University

Discussion

Member takes

Implication

Hypothesis-generating in this rat model; leaves open relevance to human hypertension.

Structured PICO

Population

Rats (sham-operated, two-kidney one-clip [2K-1C] hypertension, left renal denervation only, renal denervation of left clipped-kidney, and left renal artery clipping with renal denervation of right nonclipped kidney)

Intervention

Two-kidney, one-clip (2K-1C) Goldblatt hypertension model with or without renal denervation

Comparator

Sham-operated rats

Outcome

Monoamine contents of the striatum (dopamine, Dopac, HVA) and plasma/kidney levels of the renin-angiotensin system (ANG I, ANG II, ACE)surrogate

In a rat model of 2K-1C Goldblatt hypertension, enhanced renin-angiotensin system activity in the clipped kidney and elevated striatal monoamines appear to participate in hypertension development.

Cite This Study

Sawamura et al. (1996) studied this question.

synapsesocial.com/papers/6a98eb9d1acbc1f77078bc37 https://doi.org/10.1016/s0022-5347(01)66401-2

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Role of Dopamine in the Striatum, Renin-Angiotensin System and Renal Sympathetic Nerve on the Development of Two-Kidney, One-Clip Goldblatt Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Role of Dopamine in the Striatum, Renin-Angiotensin System and Renal Sympathetic Nerve on the Development of Two-Kidney, One-Clip Goldblatt Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider