Why the study?
Does intraventricular 6-hydroxydopamine affect the development or maintenance of hypertension in 2K-1C Goldblatt hypertensive rats?
Population
Rats with two-kidney, one clip (2K-1C) Goldblatt hypertension and normotensive age-matched sham rats
Comparison
Intraventricular injection of 6-hydroxydopamine… vs Sham rats and untreated 2K-1C rats
Design
Preclinical
Authors
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Supports role for hypothalamic norepinephrine in acute but not chronic renovascular hypertension in rats; leaves open translation to human disease.
Does intraventricular 6-hydroxydopamine affect the development or maintenance of hypertension in 2K-1C Goldblatt hypertensive rats?
Hypothalamic norepinephrine participates in the acute development of 2K-1C Goldblatt hypertension in rats, but not in its chronic maintenance.
Nakada et al. (1986) studied this question.
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