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Does intracisternal 6-hydroxydopamine affect the development of hypertension in the two kidney Goldblatt rat model?
Does intracisternal 6-hydroxydopamine affect the development of hypertension in the two kidney Goldblatt rat model?
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Sympathetic mechanisms do not appear to contribute to the development of hypertension in the two kidney Goldblatt rat model of renovascular hypertension.
1 Plasma noradrenaline concentrations were similar in rats following unilateral renal arterial constriction (two kidney Goldblatt model) and in sham-operated control rats. 2 The development of hypertension was not affected by pretreatment with intracisternal injections of 6-hydroxydopamine. 3 These data suggest that sympathetic mechanisms do not contribute to the development of hypertension in this model.
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Dargie et al. (1977) studied this question.
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