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September 23, 2008Blood Vessels

Changes in the Vascular Reactivity of the Isolated Tail Arteries of Spontaneous and Renovascular Hypertensive Rats to Endogenous and Exogenous Noradrenaline

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Key result

Spontaneously hypertensive rats showed increased vascular reactivity, whereas renovascular hypertensive rats exhibited decreased sensitivity suggesting a defect in vascular neurotransmission.

Population

Isolated tail arteries of spontaneously hypertensive rats, renovascular hypertensive rats, and normotensive…

Comparison

Vasoconstriction with exogenous noradrenaline… vs Normotensive Wistar-Kyoto (WKY) rats

Design

Preclinical

Authors

AFAbdel-Kader FoudaUniversity of LausanneAMAlfio MarazziUniversity of LausanneNBNicole BoillatUniversity of Lausanne

Discussion

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Implication

These rat model differences should not change clinical hypertension care; leaves open distinct neurotransmission defects for mechanistic studies.

Structured PICO

P
Population
Spontaneously hypertensive and renovascular hypertensive rats compared with normotensive rats to assess vascular reactivity.
E
Exposure
Vasoconstriction with exogenous noradrenaline, electrical field stimulation, or high potassium
C
Comparator
Normotensive Wistar-Kyoto (WKY) rats
O
Outcome
Vascular reactivity (vasoconstriction responses)surrogate

Spontaneously hypertensive rats exhibit increased vascular reactivity due to structural adaptation, while renovascular hypertensive rats show defects in vascular neurotransmission.

Cite This Study

Fouda et al. (2008) studied Hypertension. Hypertension (spontaneous and renovascular) vs. Normotensive rats was evaluated on Vascular reactivity to noradrenaline, electrical field stimulation, or high potassium. Spontaneously hypertensive rats showed increased vascular reactivity, whereas renovascular hypertensive rats exhibited decreased sensitivity suggesting a defect in vascular neurotransmission.

synapsesocial.com/papers/6a917e8ca84e863524466ed0https://doi.org/10.1159/000158672

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of noradrenaline on tail arteries of SHR and WKY under perfusion at constant flow and constant pressure1997 · 9 citations
  2. 2Renal vascular resistance and reactivity in the spontaneously hypertensive rat1979 · 36 citations
  3. 3Responses to noradrenaline of tail arteries in hypertensive, hypotensive and normotensive rats under different regimens of perfusion: role of the myogenic response1998 · 6 citations
  4. 4Vascular reactivity of isolated perfused kidneys from male and female spontaneously hypertensive rats.1977 · 138 citations
  5. 5Microvascular responses to norepinephrine in renovascular and spontaneously hypertensive rats1979 · 18 citations