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April 1, 1979AJP Heart and Circulatory Physiology

Microvascular responses to norepinephrine in renovascular and spontaneously hypertensive rats

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Population

Four groups of urethan-chloralose anesthetized rats: Sprague-Dawley control, Sprague-Dawley renovascular…

Comparison

Topically applied norepinephrine in… vs Normotensive control rat strains

Design

Preclinical

Authors

DWDavid L. WiegmanUniversity of LouisvilleIJIrving G. JoshuaUniversity of LouisvilleRMR. J. MorffEli Lilly (United States)

Discussion

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Implication

Microvascular differences between rat hypertension models warrant caution in human extrapolation; leaves open subtype-specific mechanisms for clinical study.

Structured PICO

P
Population
Four groups of urethan-chloralose anesthetized rats: Sprague-Dawley control (SDC), Sprague-Dawley renovascular hypertensive (RVH), Wistar-Kyoto control (WKY), and spontaneous hypertensive (SHR).
I
Intervention
Topically applied norepinephrine in progressively higher concentrations to the cremaster muscle bath
C
Comparator
Normotensive control rat strains (SDC for RVH, WKY for SHR)
O
Outcome
Vascular responses (concentration-response curves) of in vivo small arteries (50-140 micrometer diam) and veins (95-265 micrometer)surrogate

The microvascular characteristics and responses to norepinephrine differ significantly between renovascular and spontaneously hypertensive rat models.

Cite This Study

Wiegman et al. (1979) studied this question.

synapsesocial.com/papers/6a70d9168031ec7bb1dc9fechttps://doi.org/10.1152/ajpheart.1979.236.4.h545
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Changes in the Vascular Reactivity of the Isolated Tail Arteries of Spontaneous and Renovascular Hypertensive Rats to Endogenous and Exogenous Noradrenaline2008 · 15 citations
  2. 2Local renin-angiotensin system in the microcirculation of spontaneously hypertensive rats.1994 · 32 citations
  3. 3Calcium Modulation of Microvascular Sensitivity during Renovascular Hypertension1981 · 2 citations
  4. 4Arteriolar closure mediated by hyperresponsiveness to norepinephrine in hypertensive rats1979 · 78 citations
  5. 5Microvascular rarefaction in spontaneously hypertensive rat cremaster muscle1981 · 122 citations