Why the study?
Does the local renin-angiotensin system contribute to altered microcirculatory vasoconstriction in spontaneously hypertensive rats?
Does the local renin-angiotensin system contribute to altered microcirculatory vasoconstriction in spontaneously hypertensive rats?
The study demonstrates enhanced local angiotensin I conversion and angiotensinogen utilization in the microcirculation of spontaneously hypertensive rats, suggesting a hyperactive local renin-angiotensin system.
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Highlights local RAS hyperactivity in hypertensive microcirculation models; hypothesis-generating and should not yet change clinical practice.
Vicaut et al. (1994) studied this question.
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