Why the study?
Does angiotensin II produce a biphasic arteriolar response mediated by specific receptors and prostaglandin synthesis in the intact microcirculation of rats?
Population
Male Sprague-Dawley rats, anesthetized with alpha-chloralose and urethan, using the cremaster muscle with…
Comparison
Angiotensin II (ANG II, bath concn 10 M) added… vs Control diameter before adding ANG II.
Design
Preclinical
Authors
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Animal data on ANG II microvascular effects should not change practice; leaves open prostaglandin mediation for translational studies.
Does angiotensin II produce a biphasic arteriolar response mediated by specific receptors and prostaglandin synthesis in the intact microcirculation of rats?
Angiotensin II induces a biphasic arteriolar response (constriction followed by dilation) in the intact microcirculation, with the dilation phase mediated by increased prostaglandin synthesis.
Fleming et al. (1984) studied this question.
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