What question did this study set out to answer?

This research aims to investigate how short-term diabetes affects the response of arterioles to constrictors and dilators.

November 1, 1989AJP Heart and Circulatory Physiology

Altered microvascular reactivity in streptozotocin-induced diabetes in rats

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Why the study?

Does streptozotocin-induced diabetes alter microvascular reactivity to angiotensin II and vasodilatory prostaglandins in rats?

Population

Rats with short-term streptozotocin-induced diabetes

Comparison

Topical application of angiotensin II (10 to 10… vs Control rats

Design

Preclinical

Authors

MHMichael A. HillVascular / Pulmonary Vascular RLRichard G. LarkinsMonash University

Discussion

Member takes

Implication

Enhanced diabetic arteriolar constriction to ANG II may reflect prostaglandin resistance; hypothesis-generating for human microvasculature and should not change practice.

Key Points

This research aims to investigate how short-term diabetes affects the response of arterioles to constrictors and dilators.
Effect of streptozotocin-induced diabetes on arteriolar response in rat cremaster muscle
Topical administration of angiotensin II and prostaglandins
Use of cyclooxygenase inhibitors to assess vasoconstriction
Diabetic rats showed arteriolar constriction to 43% of basal diameter with ANG II (P<0.05), compared to 67% in controls.
Post-ANG II secondary vasodilation was reduced in diabetic rats (108% vs. 131%, P<0.025).
Diabetic rats displayed reduced responsiveness to vasodilatory prostaglandins despite increased PGI2 production.

Structured PICO

Does streptozotocin-induced diabetes alter microvascular reactivity to angiotensin II and vasodilatory prostaglandins in rats?

Population

Rats with short-term streptozotocin-induced diabetes

Intervention

Topical application of angiotensin II (10(-10) to 10(-6) M), cyclooxygenase inhibition (indomethacin 2.8 x 10(-5) M), and exogenous prostaglandin I2 (PGI2) and PGE2 (10(-12) to 10(-6) M)

Comparator

Control rats

Outcome

Vasoconstriction of third-order cremaster muscle arterioles in response to angiotensin IIsurrogate

Experimental diabetes in rats potentiates the vasoconstrictor response and diminishes the secondary vasodilator response to angiotensin II, likely due to decreased responsiveness to vasodilatory prostaglandins.

Cite This Study

Hill et al. (1989) studied this question.

synapsesocial.com/papers/6a7660691db26fb0a4bc4d9b https://doi.org/10.1152/ajpheart.1989.257.5.h1438

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Implication

Enhanced diabetic arteriolar constriction to ANG II may reflect prostaglandin resistance; hypothesis-generating for human microvasculature and should not change practice.

Altered microvascular reactivity in streptozotocin-induced diabetes in rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Altered microvascular reactivity in streptozotocin-induced diabetes in rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider