Population
Rats with streptozotocin-induced diabetes (blood glucose > 300 mg/dl) and nondiabetic control rats
Comparison
Superfusion with acetylcholine, ADP, thromboxane… vs Nondiabetic rats
Design
Preclinical
Authors
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May implicate TxA2-PGH2 signaling in diabetic cerebral endothelial dysfunction; hypothesis-generating, should not change practice.
Diabetes impairs endothelium-dependent vasodilation in cerebral arterioles via the production of a cyclooxygenase constrictor substance acting on TxA2-PGH2 receptors.
Mayhan et al. (1991) studied this question.
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