Key result
Acute and chronic hyperglycemia in diabetic rats were associated with near complete suppression of acetylcholine-induced vasodilation in large intestinal arterioles compared to normal rats.
Why the study?
Does streptozotocin-induced diabetes impair endothelium-mediated vasodilation in rat intestinal arterioles?
Population
Adult (20-21-week-old) rats with streptozotocin-induced diabetes (8-11 days or 7-8 weeks)
Comparison
Iontophoretic application of acetylcholine… vs Normal rats
Design
Preclinical
Follow-up
8-11 days or 7-8 weeks
Authors
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Diabetes impairs endothelium-dependent vasodilation in rat intestinal arterioles; extends animal models but leaves open human relevance.
Does streptozotocin-induced diabetes impair endothelium-mediated vasodilation in rat intestinal arterioles?
Diabetes induces a specific deficit in acetylcholine-induced endothelium-derived relaxing factor action in rat intestinal arterioles without compromising smooth muscle relaxation or bradykinin-stimulated relaxation.
Lash et al. (1991) studied Streptozotocin-induced diabetes. Streptozotocin-induced diabetes vs. Normal rats was evaluated on Acetylcholine-induced vasodilation. Acute and chronic hyperglycemia in diabetic rats were associated with near complete suppression of acetylcholine-induced vasodilation in large intestinal arterioles compared to normal rats.
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