June 1, 1990AJP Heart and Circulatory Physiology
Angiotensin II induces endothelium-dependent vasodilation of rat cerebral arterioles
Population
Anesthetized rats equipped with a closed cranial window
Comparison
Topical application of angiotensin II (10-10 M) vs Co-application with indomethacin, methylene…
Design
Preclinical
Authors
Discussion
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Implication
ANG II may elicit COX-mediated endothelium-dependent vasodilation in rat cerebral arterioles; leaves open translation to human cerebrovascular regulation.
Structured PICO
P
Population
Anesthetized rats equipped with a closed cranial window
I
Intervention
Topical application of angiotensin II (10(-10)-10(-5) M)
C
Comparator
Co-application with indomethacin, methylene blue, or endothelial damage (mercury light illumination after intravenous injection of fluorescein dye)
O
Outcome
Arteriolar vasodilation/vasoconstrictionsurrogate
Angiotensin II induces endothelium-dependent vasodilation in rat cerebral arterioles, likely mediated by a cyclooxygenase-dependent mechanism.
Cite This Study
Haberl et al. (1990) studied this question.