Angiotensin II induces endothelium-dependent constriction of pial arterioles in vivo in mice.
Endothelial modulation of Ang II vasoconstriction in murine pial arterioles; leaves open translation to human cerebrovascular disease.
Pial arterioles 30-50 μ m wide were monitored in vivo using a television - microscopy -image splitting technique. Topical angiotensin II constricted the vessels in dose dependent manner. Selective endothelial injury with a helium neon laser/Evans blue technique abolished modest responses to All and greatly reduced larger responses. Thus, All produces endothelium dependent constriction of arterioles in vivo in this portion of the brains micro vascular tree.
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Rosenblum et al. (1995) studied this question.
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