Key result
Angiotensin II induced strong contractions in the mouse abdominal aorta (75.1%) and femoral artery (76.0%), but significantly less in the carotid artery (24.5%) and thoracic aorta (3.5%).
Major mouse vessels exhibit differential contractions to ANG II, likely due to varied AT1 receptor levels, highlighting the importance of vessel selection in murine cardiovascular models.
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Marked regional Ang II responsiveness in mouse arteries cautions against uniform vascular models; leaves open mechanisms and human translation.
Zhou et al. (2003) studied this question. Angiotensin II vs. 60 mM K+ was evaluated on Maximum contraction compared with 60 mM K+. Angiotensin II induced strong contractions in the mouse abdominal aorta (75.1%) and femoral artery (76.0%), but significantly less in the carotid artery (24.5%) and thoracic aorta (3.5%).