Population
AT1a-/- mice and wild-type littermates (AT1a+/+)
Comparison
In vitro Angiotensin II exposure with or without… vs Wild-type littermates (AT1a+/+)
Design
Preclinical
Authors
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Mouse data on AT1b predominance do not alter human therapy; leaves open subtype roles in clinical vascular disease.
In mice, the AT1b receptor, rather than AT1a, predominantly mediates Angiotensin II-induced contractions in major blood vessels like the abdominal aorta and femoral artery.
Zhou et al. (2003) studied this question.
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