Why the study?
Does the AT(1B) receptor mediate contraction in the abdominal aorta in response to angiotensin II in mice?
Population
Male wild-type and AT(1B) receptor knockout mice (abdominal aortic rings)
Comparison
Angiotensin II vs Wild-type mice vs AT(1B) receptor knockout mice
Design
Preclinical
Authors
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Does not alter human AT1 blocker use; leaves open translation of murine AT1B predominance to clinical vascular pharmacology.
Does the AT(1B) receptor mediate contraction in the abdominal aorta in response to angiotensin II in mice?
The AT(1B) receptor is the predominant receptor mediating contraction in the mouse abdominal aorta in response to angiotensin II, paralleling the function of the single known AT(1) receptor in human vascular smooth muscle.
SWAFFORDJR et al. (2007) studied this question.
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