Population
Normal Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats observed at age 5-7 weeks and 16-18 weeks
Comparison
Denervation of the cremasteric muscle vs Age-matched WKY rats vs SHR rats
Design
Preclinical
Authors
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No early arteriolar remodeling in SHR rats; leaves open whether microcirculatory changes emerge later or contribute to hypertension in other models.
The study found no evidence of abnormal vessel wall hypertrophy, vasoconstriction, or increased sympathetic activity in the microcirculation of spontaneously hypertensive rats up to 16-18 weeks of age.
Bohlen et al. (2008) studied this question.
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