Key result
Renal artery clipping in spontaneously hypertensive rats produced a 21% rise in systolic blood pressure versus 44% in Wistar-Kyoto rats, with greater mesenteric arterial hypertrophy.
Why the study?
Does renal artery clipping produce more extensive cardiovascular hypertrophy in spontaneously hypertensive rats compared to Wistar-Kyoto rats?
Population
6-week-old spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats
Comparison
Two-kidney, one clip renal hypertension vs Sham operation
Design
Preclinical
Follow-up
4 weeks
Authors
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Greater hypertrophic response in SHR despite smaller BP rise; hypothesis-generating for remodeling mechanisms in secondary hypertension.
Does renal artery clipping produce more extensive cardiovascular hypertrophy in spontaneously hypertensive rats compared to Wistar-Kyoto rats?
Absolute Event Rate: 21% vs 44%
Spontaneously hypertensive rats exhibit an exaggerated hypertrophic response in the left ventricle and mesenteric vasculature to renal hypertension compared to normotensive rats, despite a smaller relative increase in blood pressure.
Dilley et al. (1994) studied Renal hypertension. Renal artery clipping vs. Sham operation (with comparison between SHR and WKY strains) was evaluated on Rise in systolic blood pressure. Renal artery clipping in spontaneously hypertensive rats produced a 21% rise in systolic blood pressure versus 44% in Wistar-Kyoto rats, with greater mesenteric arterial hypertrophy.
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