Key result
Vascular smooth muscle cells from spontaneously hypertensive rats exhibited enhanced proliferation, higher cell density at quiescence, and less susceptibility to growth inhibition by TGF-beta 1.
Population
Vascular smooth muscle cells from spontaneously hypertensive rats and normotensive Wistar-Kyoto rats
Comparison
Exposure to foetal calf serum and Transforming… vs VSMC from normotensive Wistar-Kyoto (WKY) rats
Design
Preclinical
Authors
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May inform VSMC-targeted hypertension research; leaves open translation to human disease or therapy.
Vascular smooth muscle cells from spontaneously hypertensive rats show enhanced proliferation and resistance to TGF-beta 1 growth inhibition, which may contribute to vascular hypertrophy.
Saltis et al. (1992) studied Genetic hypertension. Spontaneously hypertensive rat (SHR) strain vs. Normotensive Wistar-Kyoto (WKY) rats was evaluated on Growth characteristics (growth rates and cell density at quiescence) and response to TGF-beta 1. Vascular smooth muscle cells from spontaneously hypertensive rats exhibited enhanced proliferation, higher cell density at quiescence, and less susceptibility to growth inhibition by TGF-beta 1.
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