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November 1, 1995Clinical and Experimental Pharmacology and Physiology

Molecular Mechanisms of Vascular Hypertrophy in the Spontaneously Hypertensive Rat

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Population

Cultured spontaneously hypertensive rat-derived vascular smooth muscle cells or aortic adventitial fibroblasts

Design

Review

Authors

PMPatrice N. MarcheCentre National de la Recherche ScientifiqueTHThierry HérembertDélégation Paris 5DZDonglin ZhuZhejiang Normal University

Discussion

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Implication

Excludes early receptor/signaling defects in SHR vascular hyperplasia; leaves open distal events as focus for hypertension mechanism studies.

Structured PICO

P
Population
Cultured spontaneously hypertensive rat (SHR)-derived vascular smooth muscle cells or aortic adventitial fibroblasts
I
Intervention
Various polypeptide growth factors and vasoactive agents
O
Outcome
Cell growth and related biochemical events

The abnormal hyperproliferation of vascular cells in spontaneously hypertensive rats is likely driven by distal events in cell growth signaling rather than early receptor-mediated pathways.

Cite This Study

Marche et al. (1995) studied this question.

synapsesocial.com/papers/6a87c4dc02f504243ce95f31https://doi.org/10.1111/j.1440-1681.1995.tb02844.x

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Involvement of Calcium Channels in Fibroblast Growth Factor-Induced Activation of Arterial Cells in Spontaneously Hypertensive Rats1994 · 12 citations
  2. 2Contractile response of spontaneously hypertensive rat caudal artery to phorbol esters.1988 · 12 citations
  3. 3The Phosphoinositide Signalling System and Hypertension1987 · 59 citations
  4. 4Abnormalities in growth characteristics of aortic smooth muscle cells in spontaneously hypertensive rats.1989 · 176 citations
  5. 5Effects of hypertension and aging on platelet-derived growth factor and platelet-derived growth factor receptor expression in rat aorta and heart.1991 · 53 citations