Key result
Insulin normalizes elevated platelet growth-promoting activity, but hydrochlorothiazide enhances it unlike other antihypertensives.
Population
Spontaneously hypertensive rats and normotensive Wistar-Kyoto rats; diabetic and hypertensive patients and…
Comparison
Exposure to growth factors, intensive insulin… vs Normotensive WKY rats, healthy controls, or…
Design
Preclinical
Authors
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Should not yet alter antihypertensive selection; hypothesis-generating for platelet growth-promoting activity in diabetic and hypertensive vasculopathy.
Intrinsic growth anomalies in vascular smooth-muscle cells and altered platelet growth-promoting activity may play a primary role in the vascular pathology of hypertension and diabetes.
Mikhail et al. (1993) studied Hypertension and Diabetes. Hypertension and Diabetes vs. Normotensive and healthy controls was evaluated on Platelet growth-promoting activity (GPA) and VSMC proliferation. Platelet growth-promoting activity was elevated in diabetic and hypertensive patients, normalized by insulin, but enhanced by hydrochlorothiazide (25 mg/day) unlike other antihypertensives.
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