Why the study?
Does activation with PDGF and Ang II alter cytosolic free calcium concentration differently in vascular smooth muscle cells from spontaneously hypertensive rats compared to normotensive rats?
Population
Cultured aortic smooth muscle cells from spontaneously hypertensive rats and Wistar-Kyoto normotensive rats
Comparison
Activation with Angiotensin II and… vs WKY normotensive rat cells and basal states
Design
Preclinical
Authors
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No immediate clinical implications; leaves open mechanistic translation of enhanced calcium responses in this SHR model.
Does activation with PDGF and Ang II alter cytosolic free calcium concentration differently in vascular smooth muscle cells from spontaneously hypertensive rats compared to normotensive rats?
Vascular smooth muscle cells from spontaneously hypertensive rats exhibit exaggerated calcium signaling responses to PDGF and Angiotensin II compared to normotensive controls.
Bendhack et al. (1992) studied this question.
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