Population
Aortic smooth muscle cells from spontaneously hypertensive rats and normotensive Wistar-Kyoto rats
Comparison
Angiotensin II (100 nM) and ionomycin vs Confluent and postconfluent cultures; WKY VSMCs
Design
Preclinical
Authors
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Ca2+ handling changes in SHR VSMCs dissociate from proliferation; leaves open their role in hypertensive remodeling.
Alterations in ANG II AT1 receptor density and intracellular Ca2+ handling in confluent cultures are not associated with the proliferative phenotype of SHR VSMCs.
Côrtes et al. (1996) studied this question.
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