Angiotensin II mediates vascular smooth muscle cell hypertrophy and proliferation via the AT1 receptor, with enhanced effects in spontaneously hypertensive rats, providing a mechanistic basis for their greater response to AT1 blockade.
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Enhances mechanistic understanding of AT1 signaling in hypertensive vascular cells; leaves open translation to human disease.
Bunkenburg et al. (1992) studied this question.
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