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January 1, 1999Sunhwan'gi

Effects of Angiotensin II on the Growth of Vascular Smooth Muscle Cells

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Why the study?

Does angiotensin II induce cellular hypertrophy or mitogenic activity in cultured rat aortic vascular smooth muscle cells?

Population

Cultured rat aortic smooth muscle cells obtained by combined collagenase and elastase methods

Design

Preclinical

Follow-up

3 days

Authors

KKKyung Man KimIKIn Seop KimHannam UniversitySPSu Je Park

Discussion

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Overview

Ang II induces VSMC hypertrophy without mitogenesis in vitro; hypothesis-generating for vascular remodeling mechanisms.

Structured PICO

Does angiotensin II induce cellular hypertrophy or mitogenic activity in cultured rat aortic vascular smooth muscle cells?

P
Population
Cultured rat aortic smooth muscle cells (between 4th and 8th passages) obtained by combined collagenase and elastase methods
I
Intervention
Angiotensin II alone or angiotensin II with equimolar concentrations of saralasin, treated daily for 3 days
O
Outcome
Cellular hypertrophy and mitogenic activity measured by incorporated radioactivity of (3H)thymidine and (14C)phenylalaninesurrogate

Angiotensin II induces cellular hypertrophy but lacks detectable mitogenic activity in cultured rat aortic vascular smooth muscle cells.

Cite This Study

Kim et al. (1999) studied this question.

synapsesocial.com/papers/6a8d1a75b7e5f37e3ddacdf0https://doi.org/10.4070/kcj.1999.29.2.209
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