July 1, 1999Journal of Hypertension

Angiotensin II stimulates DNA and protein synthesis in vascular smooth muscle cells from human arteries

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Population

Cultured vascular smooth muscle cells derived from resistance arteries from subcutaneous gluteal biopsies of…

Comparison

Angiotensin II (10 - 10 mol/l), evaluated in the… vs Control (untreated cells) and endothelin-1.

Design

Preclinical

Authors

RTRhian M. TouyzMcGill University Health Centre LDLi-Yuan DengMedical Council of Canada GHGang HeBethune International Peace Hospital

Discussion

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Implication

Does not support clinical changes; leaves open translation of AT1-ERK vascular proliferation to human hypertension.

Structured PICO

Population

Cultured vascular smooth muscle cells derived from resistance arteries (< 300 microm diameter) from subcutaneous gluteal biopsies of healthy subjects (n = 6) and human aortic vascular smooth muscle cells (studied between passages 3 and 6).

Intervention

Angiotensin II (10(-12) - 10(-6) mol/l), evaluated in the absence and presence of losartan (10(-5) mol/l), PD123319 (10(-5) mol/l), or PD98059 (10(-5) mol/l).

Comparator

Control (untreated cells) and endothelin-1.

Outcome

Vascular smooth muscle cell hyperplasia (DNA synthesis measured by 3H-thymidine incorporation) and cell hypertrophy (protein synthesis measured by 3H-leucine incorporation).surrogate

Angiotensin II stimulates hyperplasia and hypertrophy in human vascular smooth muscle cells via AT1 receptor-mediated, ERK-dependent signaling pathways.

Cite This Study

Touyz et al. (1999) studied this question.

synapsesocial.com/papers/6a200937d5e8712fdf65b93f https://doi.org/10.1097/00004872-199917070-00006

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Angiotensin II stimulates DNA and protein synthesis in vascular smooth muscle cells from human arteries

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin II stimulates DNA and protein synthesis in vascular smooth muscle cells from human arteries

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider