Why the study?
Does the Angiotensin II inhibitor E4177 prevent abnormal growth of vascular smooth muscle cells in vitro and in vivo?
Population
Animal model of vein graft transplantation and primary culture of human aortic smooth muscle cells (HASMC)
Comparison
Angiotensin II inhibitor E4177 vs Control (untreated or Angiotensin II alone)
Design
Preclinical
Authors
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E4177 counters Ang II-driven smooth muscle cell growth in vitro; hypothesis-generating for vascular remodeling, no clinical implications yet.
Does the Angiotensin II inhibitor E4177 prevent abnormal growth of vascular smooth muscle cells in vitro and in vivo?
Angiotensin II promotes vascular smooth muscle cell growth and cell surface area enlargement, effects that can be blocked by the AngII inhibitor E4177.
Kuma et al. (2007) studied this question.