Why the study?
Does angiotensin II stimulate growth of human coronary artery smooth muscle cells and which receptor mediates this response?
Population
Human coronary artery smooth muscle cells isolated from coronary arteries of recipient hearts obtained…
Comparison
Angiotensin II with or without pretreatment with… vs Untreated cells
Design
Preclinical
Follow-up
48 h
Authors
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Does not support altering ARB use in CAD; leaves open whether AT1-mediated cSMC growth contributes to human coronary remodeling.
Does angiotensin II stimulate growth of human coronary artery smooth muscle cells and which receptor mediates this response?
Angiotensin II stimulates protein synthesis in human coronary smooth muscle cells via the AT1 receptor, providing a potential mechanism for vascular wall thickening in coronary artery disease.
Hafizi et al. (1998) studied this question.
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