Key result
Angiotensin II contributes to cardiovascular disease and hypertension by inducing vascular smooth muscle cell remodeling.
Angiotensin II plays a key role in vascular smooth muscle cell remodeling, contributing to hypertension and cardiovascular disease.
May attenuate Ang II-driven VSMC remodeling via MAPK inhibition in vitro; leaves open clinical translation for hypertension or atherosclerosis.
Angiotensin II (Ang II) is a main effector peptide of the renin-angiotensin system that plays an important role in various cardiovascular diseases associated with vascular smooth muscle cell (VSMC) proliferation and migration, including hypertension, atherosclerosis and myocardial infarction (1). Ang II causes a rapid rise in blood pressure by stimulating Ang II type 1 receptor in arterial VSMC to contract. Ang II is also associated with the slow onset of hypertension by cardiac and vascular remodeling induced by cardiovascular cellular hypertrophy, proliferation and migration (2).
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Yoshizumi et al. (2020) conducted a review in Cardiovascular diseases (hypertension, atherosclerosis, myocardial infarction). Angiotensin II was evaluated. Angiotensin II contributes to cardiovascular diseases and hypertension by inducing vascular smooth muscle cell hypertrophy, proliferation, migration, and remodeling.
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