Why the study?
Does blockade of angiotensin II formation inhibit vascular smooth muscle cell hypertrophy, hyperplasia, and remodeling in response to hypertension and arterial injury?
Population
Animal models of hypertension and arterial injury; vascular smooth muscle cells
Design
Review
Authors
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May guide therapy development for vascular remodeling; leaves open translation from animal models to human hypertension and restenosis.
Does blockade of angiotensin II formation inhibit vascular smooth muscle cell hypertrophy, hyperplasia, and remodeling in response to hypertension and arterial injury?
The tissue renin-angiotensin system plays a key role in vascular remodeling, and its inhibition may be important for treating hypertension, atherosclerosis, and restenosis.
Allen J. Naftilan (1994) studied this question.
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