January 1, 1993
Local expression and pathophysiological role of renin-angiotensin in the blood vessels and heart
Key result
Endogenous tissue renin-angiotensin systems, particularly local angiotensin II and ACE, play important roles in long-term cardiovascular regulation, vascular hypertrophy, and the pathophysiology of heart failure.
Design
Review
Authors
Discussion
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Member takes
Implication
May guide RAS inhibitor strategies in HF; leaves open tissue-specific targeting for future trials.
PICO
P
Population
Cardiovascular homeostasis and pathophysiology
I
Intervention / Comparator
ACE inhibitors / Angiotensin II
Endogenous tissue renin-angiotensin systems play a critical role in long-term cardiovascular regulation, including vascular remodeling, hypertrophy, and heart failure.
Cite This Study
Victor J. Dzau (1993) conducted a review in Cardiovascular homeostasis and pathophysiology. ACE inhibitors / Angiotensin II was evaluated. Endogenous tissue renin-angiotensin systems, particularly local angiotensin II and ACE, play important roles in long-term cardiovascular regulation, vascular hypertrophy, and the pathophysiology of heart failure.