Key result
Endogenous tissue renin-angiotensin systems, particularly local angiotensin II and ACE, play important roles in long-term cardiovascular regulation, vascular hypertrophy, and the pathophysiology of heart failure.
Endogenous tissue renin-angiotensin systems play a critical role in long-term cardiovascular regulation, including vascular remodeling, hypertrophy, and heart failure.
No takes yet. Share an insight, caveat, or question.
May guide RAS inhibitor strategies in HF; leaves open tissue-specific targeting for future trials.
Victor J. Dzau (1993) conducted a review in Cardiovascular homeostasis and pathophysiology. ACE inhibitors / Angiotensin II was evaluated. Endogenous tissue renin-angiotensin systems, particularly local angiotensin II and ACE, play important roles in long-term cardiovascular regulation, vascular hypertrophy, and the pathophysiology of heart failure.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: