Key result
Experimental evidence suggests a critical role for the renin-angiotensin system and Angiotensin II-receptor signaling in the development of cardiac hypertrophy and failure.
Population
Experimental animal models and patients with heart failure and cardiac hypertrophy
Design
Review
Authors
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Supports independent cardiac RAS activation in HF; leaves open whether local targeting improves outcomes beyond systemic blockade.
This review highlights the critical role of the local cardiac renin-angiotensin system and Ang II-receptor signaling in the pathophysiology of cardiac hypertrophy and failure.
Kai C. Wollert (1999) conducted a review in Cardiac hypertrophy and failure. Renin-angiotensin system (RAS) and Angiotensin II was evaluated. Experimental evidence suggests a critical role for the renin-angiotensin system and Angiotensin II-receptor signaling in the development of cardiac hypertrophy and failure.
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