Key result
ACE inhibitors and AT1 antagonists prevent or reverse angiotensin II-driven cardiac hypertrophy in rat models.
Population
Rat cardiomyocytes in culture and experimental rat models
Design
Review
Authors
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Rat model data should not change practice; confirms AT1-mediated hypertrophy mechanisms but leaves open human translation.
The review summarizes preclinical evidence that local Angiotensin II mediates cardiac hypertrophy and gene expression via AT1 receptors, providing a mechanistic basis for the use of ACE inhibitors and ARBs in preventing or reversing myocardial hypertrophy.
Lijnen et al. (1999) conducted a review in Cardiac hypertrophy. Angiotensin II and RAS antagonists was evaluated. Angiotensin II mediates cardiac myocyte hypertrophy and gene expression via AT1 receptors, which can be prevented or reversed by ACE inhibitors and AT1 receptor antagonists in rat models.
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