May 13, 2005Experimental Physiology
Intracellular mechanisms involved in vascular remodelling of resistance arteries in hypertension: role of angiotensin II
Design
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Authors
Discussion
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Implication
May guide targeted antihypertensives; leaves open whether pathway inhibition regresses resistance artery remodelling in patients.
Key Points
- To review the intracellular signaling cascades through which angiotensin II drives vascular remodeling, cell growth, and inflammation in resistance arteries during hypertension.
- Narrative synthesis of cellular and molecular pathways underlying structural resistance artery remodeling in hypertensive states.
- Evaluation of angiotensin II-stimulated downstream mediators, including PLC-IP3-DAG cascades, MAP kinases, tyrosine kinases, RhoA/Rho kinase, and NADPH oxidase-derived reactive oxygen species.
- Vascular remodeling in hypertension features media thickening, reduced lumen diameter, increased extracellular matrix deposition, vascular smooth muscle cell phenotypic alteration, and macrophage-driven inflammation.
- Angiotensin II coordinates these structural changes by activating multi-tiered intracellular pathways, including PLC, MAP kinases, and vascular NADPH oxidase to generate reactive oxygen species (*O2- and H2O2).
Cite This Study
Rhian M. Touyz (2005) studied this question.