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April 1, 2001British Journal of PharmacologyOpen Access

Intracellular Angiotensin II and cell growth of vascular smooth muscle cells

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Population

A7r5 smooth muscle cells

Comparison

Intracellular application of Angiotensin II via… vs Quiescent cells and extracellular Angiotensin II

Design

Preclinical

Authors

CFCatalin M. FilipeanuRHRobert H. HenningDZDick de Zeeuw

Discussion

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Overview

Intracellular Ang II effects on VSMC growth remain preclinical; leaves open whether atypical receptors represent a human therapeutic target.

Structured PICO

P
Population
A7r5 smooth muscle cells
I
Intervention
Intracellular application of Angiotensin II via liposomes
C
Comparator
Quiescent cells (absence of intracellular Angiotensin II) and extracellular Angiotensin II
O
Outcome
Cell growth measured by [(3)H]-thymidine incorporation (DNA synthesis) and cell numbersurrogate

Intracellular Angiotensin II induces vascular smooth muscle cell growth through atypical AT-receptors via PI-3K and MAPK/ERK-sensitive pathways, independent of plasma membrane receptors.

Cite This Study

Filipeanu et al. (2001) studied this question.

synapsesocial.com/papers/6a910f2e780df83b8fe1b739https://doi.org/10.1038/sj.bjp.0703984
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