Why the study?
Does Angiotensin II stimulate growth and activate Na+-H+ exchange in cultured vascular smooth muscle cells?
Population
Cultured vascular smooth muscle cells
Comparison
Angiotensin II (dose-dependent, 10 to 10 mol/l) vs Control cells
Design
Preclinical
Authors
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Should not change practice; leaves open translation of Ang II effects on VSMC growth to human vascular disease.
Does Angiotensin II stimulate growth and activate Na+-H+ exchange in cultured vascular smooth muscle cells?
Angiotensin II stimulates vascular smooth muscle cell growth, potentially mediated by intracellular alkalinization via Na+-H+ exchange activation.
Lyall et al. (1988) studied this question.
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