Why the study?
Does hypertension enhance the vascular myogenic response in skeletal muscle arterioles?
Population
Spontaneously hypertensive rats and normotensive Wistar-Kyoto rats
Comparison
Increasing venous pressure in vivo and step… vs Normotensive WKY rats
Design
Preclinical
Authors
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Supports enhanced myogenic reactivity in hypertensive rat arterioles; leaves open human translation and clinical relevance.
Does hypertension enhance the vascular myogenic response in skeletal muscle arterioles?
Skeletal muscle arterioles from spontaneously hypertensive rats exhibit an enhanced myogenic response and altered length-tension curve compared to normotensive rats, independent of adrenergic hypersensitivity or structural wall changes.
Falcone et al. (1993) studied this question.
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