November 1, 1997Hypertension

Endothelin and Prostaglandin H2Enhance Arteriolar Myogenic Tone in Hypertension

View Full Paper

Ask AI

Bookmark

Population

Isolated, cannulated arterioles from cremaster muscles of 30-week-old normotensive Wistar Kyoto and…

Comparison

Inhibition of thromboxane A2-PGH2 receptors by… vs Arterioles from normotensive WKY rats

Design

Preclinical

Authors

AHAn HuangFirst Affiliated Hospital of Jiangxi Medical College ÁKÁkos KollerVascular Medicine

Discussion

Member takes

Implication

Endothelial ET-A signaling may enhance arteriolar myogenic tone in hypertension; leaves open translation to human resistance vessels.

Structured PICO

Population

Isolated, cannulated arterioles (approximately 60 microm) from cremaster muscles of 30-week-old normotensive Wistar Kyoto (WKY) and spontaneously hypertensive (SH) rats

Intervention

Inhibition of thromboxane A2-PGH2 receptors by SQ 29,548, removal of endothelium, or administration of BQ-123 (ET-A receptor blocker) during pressure-induced constrictions

Comparator

Arterioles from normotensive WKY rats

Outcome

Changes in the diameter of isolated, cannulated arterioles as a function of perfusion pressure (20 to 140 mm Hg)surrogate

In spontaneously hypertensive rats, enhanced arteriolar constriction to increased intravascular pressure is mediated by endothelium-derived prostaglandin H2 and endothelin.

Cite This Study

Huang et al. (1997) studied this question.

synapsesocial.com/papers/6a6f98fefebe604dd7087b70 https://doi.org/10.1161/01.hyp.30.5.1210

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Endothelin and Prostaglandin H2Enhance Arteriolar Myogenic Tone in Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Endothelin and Prostaglandin H2Enhance Arteriolar Myogenic Tone in Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider