In hypertension, endothelium-derived endothelin and PGH2/TxA2 enhance myogenic constriction by increasing the calcium sensitivity of arteriolar smooth muscle rather than increasing intracellular calcium levels.
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TxA2/ETA inhibition may blunt enhanced myogenic tone in hypertension; hypothesis-generating for human translation and should not yet change practice.
Ungvári et al. (2000) studied this question.
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