Population
Isolated, cannulated first-order arterioles from the rat cremaster muscle of spontaneously hypertensive and…
Comparison
Changes in intraluminal pressures and… vs Normotensive rats, intact vs denuded…
Design
Preclinical
Authors
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Endothelin contributes to pressure-induced constriction in hypertensive rat arterioles; hypothesis-generating and should not yet change practice.
In hypertensive rats, arteriolar vasomotor responses to high intraluminal pressure involve both intrinsic myogenic mechanisms and endothelial cell release of endothelin.
Falcone et al. (1999) studied this question.
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