July 1, 1996Journal of Hypertension

Both nitric oxide and prostaglandin-mediated responses are impaired in skeletal muscle arterioles of hypertensive rats

View Full Paper

Ask AI

Bookmark

Population

Isolated, cannulated, pressurized gracilis muscle arterioles of normotensive Wistar-Kyoto rats and…

Comparison

Application of vasoactive agents with or without… vs Normotensive Wistar-Kyoto (WKY) rat arterioles

Design

Preclinical

Authors

AHAn HuangFirst Affiliated Hospital of Jiangxi Medical College ÁKÁkos KollerVascular Medicine

Discussion

Member takes

Implication

Endothelial dysfunction in hypertensive arterioles may involve impaired NO and enhanced constrictor prostaglandins; hypothesis-generating and leaves open human relevance.

Structured PICO

Population

Isolated, cannulated, pressurized (at 80 mmHg) gracilis muscle arterioles (45-50 microns diameter) of normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR)

Intervention

Application of vasoactive agents (Acetylcholine, sodium nitroprusside, Substance P, calcium ionophore A23187) with or without endothelial removal, indomethacin, SQ 29548, or NG-nitro-L-arginine

Comparator

Normotensive Wistar-Kyoto (WKY) rat arterioles

Outcome

Vascular responsiveness (dilation or constriction) to vasoactive agentssurrogate

Endothelial dysfunction in hypertensive rats involves both impaired nitric oxide pathways and enhanced production of constricting prostaglandins like PGH2 in skeletal muscle arterioles.

Cite This Study

Huang et al. (1996) studied this question.

synapsesocial.com/papers/6a730d2f8ca63dee9860e47a https://doi.org/10.1097/00004872-199607000-00012

Topics

Thymosin beta-4

View Full Paper

Ask AI

Bookmark

Implication

Endothelial dysfunction in hypertensive arterioles may involve impaired NO and enhanced constrictor prostaglandins; hypothesis-generating and leaves open human relevance.

Both nitric oxide and prostaglandin-mediated responses are impaired in skeletal muscle arterioles of hypertensive rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Both nitric oxide and prostaglandin-mediated responses are impaired in skeletal muscle arterioles of hypertensive rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider